UBE3A and esophageal cancer: Analysis of the expression level of UBE3A in cancer tissues, compared with non-tumor tissues, revealed that UBE3A was significantly upregulated in large B-cell lymphoma, esophageal cancer, thymoma, pancreatic cancer, and prostate cancer ( P < 0.01) through analyzing the GEPIA web tool (http://gepia.cancer-pku.cn/) (Figure 1A).