Especially, in silico analysis of glioma tissues of the multidimensional data set from TCGA revealed that CD147 are broadly positive associated with Nrf2 target genes regulating redox homeostasis, including NQO-1, HO-1, GSTK-1, and GSS (Figure 6D-6G), which further confirmed the CD147 regulation of Nrf2. This evidence concerns the gene GSS and central nervous system cancer.