HMOX1 and neoplasm: Firstly, Nrf2 enhances the antioxidant defense system of cells by inducing the synthesis of various antioxidant enzymes, such as HO-1, NQO-1 and GCLC-1, which are critical for the induction of Nicotinamide adenine dinucleotide phosphate (NADPH) and glutathione (GSH), contributing to anti-oxidative stress and promotion of tumor cell viability 5, 6.