International scientific databases including Scopus, Web of Science, and MEDLINE as well as national databases including Meh Iran, SID, and Iran Doc were reviewed with the following keywords: SARS-CoV-2, COVID-19, coronavirus, ACE, angiotensin II, angiotensin-converting enzyme 2, Ang-(1-7), testes, male reproductive system, male fertility, and semen. This evidence concerns the gene ACE2 and COVID-19.