Regarding SARS-CoV-2-induced immune responses, the current state of knowledge indicates that innate immunity mechanisms along with the adaptive immune system and its components, i.e., CD4+ T cells/CD8+ T cells and the antibodies [including neutralizing antibodies (NAbs)] produced by B cells/plasma cells contribute to control of SARS-CoV-2 in both non-hospitalized and hospitalized cases of COVID-19 [7–11]. The gene discussed is CD4; the disease is COVID-19.