PTPN2 and infection: In line with a failure to induce M2 macrophages, Ptpn2-LysMCre mice suffered from more pronounced N. brasiliensis-induced weight loss, elevated red blood cell counts in bronchio-alveolar lavages (BAL) between day 2–7 post infection, enhanced lung pathology, and an increase in infiltrating cells, including neutrophils and eosinophils in BAL 7 days post infection (Fig. 7a–d, Supplementary Figs. S9, S10a+b).