In line with our in vitro findings that addition of IL-6Rα to the cell culture medium was able to restore the ability of PTPN2-knockdown macrophages to develop into M2 macrophages, injection of IL-6Rα during infection with N. brasiliensis ameliorated infection-induced weight loss and lung pathology in Ptpn2-LysMCre mice (Supplementary Fig. S12). Here, IL6R is linked to infection.