Our results showed that high USP14 expression was positively associated with the differentiation of HCC, but has no relationship with other clinicopathological features, including age, gender, cirrhosis, tumor size, perihepatic organ invasion, vascular invasion, lymph node metastasis, and TNM (tumor, lymph node, and metastasis) state (Fig. 1E, Table S1). This evidence concerns the gene USP14 and Cirrhosis.