USP14 and hepatocellular carcinoma: Consistent with the previous findings of USP14 in hepatocellular carcinoma [35], our study has demonstrated the key role of USP14 in determining the clinical severity and prognosis of patients, and thus to explore the anticancer efficacy of USP14 inhibitor IU1 as a potential hepatocellular carcinoma therapeutic agent in vivo and in vitro.