For example, researchers have suggested that VAT is closely associated with inflammatory cytokines (e.g., interleukin-6 and tumour necrosis factor-alpha) which may potentially affect the tumour microenvironment [10, 52], while subcutaneous tissue-derived factors such as leptin may act in contrast by increasing insulin sensitivity and lipid metabolism, thereby, effectively improving survival [52–55]. The gene discussed is IL6; the disease is neoplasm.