The incidence of diabetes (blood glucose > 13.8 mM) was increased in both female (93.75% vs. 65%, p < 0.001) and male (84.62% vs. 13.33%, p < 0.0001) Mbd2−/− NOD mice along with an early onset of T1D (11.47 ± 1.10 vs. 17.85 ± 1.06 weeks for females, and 14.17 ± 1.06 vs. 29.0 ± 1.0 weeks for males) (Fig. 1A). Here, MBD2 is linked to type 1 diabetes mellitus.