PLA2G7 and myocardial ischemia: In SOLID-TIMI 52 (the stabilization of plaque using darapladib-thrombolysis in myocardial infarction 52) trial [31], direct inhibition of Lp-PLA2 with darapladib in patients with ACS failed to reduce the risk of future cardiovascular death, MI, or urgent coronary revascularization for myocardial ischemia.