From the perspective of the tumor, the mechanism of immune evasion includes PD-L1 upregulation to induce T-cell exhaustion, Fas-L upregulation to induce T-cell apoptosis, low expression of the MHC complex to decrease TCR stimulation, and upregulation of CD47 to induce the “Don’t eat me” signal of macrophages. The gene discussed is CD274; the disease is neoplasm.