IFNG and neoplasm: For example, lipid nanocapsules loaded with a rhenium-188 lipophilic complex used during the fractionated internal radiation of glioblastoma and hepatocellular carcinoma models led to increased cytokine (IL-2 and IFN-γ) production, increased inflammatory cell infiltration, and increased expression of MHC class I and class II in tumor sites [66, 67].