Nine rewired nodes COL3A1, CXCL9, CYCS, CXCL10, THY1, COL1A2, SAA1, CDKN1A, and JUN were commonly included in both health- and obesity-NAFL-NASH sequences (Fig. 3C). Here, CXCL10 is linked to obesity due to melanocortin 4 receptor deficiency.