Nine rewired nodes COL3A1, CXCL9, CYCS, CXCL10, THY1, COL1A2, SAA1, CDKN1A, and JUN were commonly included in both health- and obesity-NAFL-NASH sequences (Fig. 3C). The gene discussed is SAA1; the disease is obesity due to melanocortin 4 receptor deficiency.