Moreover, loss-of-function mutation in the ARID1B gene or downregulation of ARID1B expression in medulloblastoma leads to an increase in PI3K/Akt signaling due to decreased expression of negative regulators of Akt such as dual specificity phosphatase 2, thyroid transcription factor 1, leucine zipper tumor suppressor 1, DAB2 interacting protein and protein tyrosine phosphatase receptor type U [247]. Here, AKT1 is linked to medulloblastoma.