In patients with locally advanced or metastatic gastric cancer and gastric-esophageal junction cancer, combination of the ATP-competitive pan-Akt inhibitor ipatasertib with leucovorin, 5-FU and oxalipatin does not improve the progression-free survival even in PTEN-low and PI3K/Akt pathway-activated subgroup [214]. This evidence concerns the gene AKT1 and gastric cancer.