In the early phase of cerebral ischemia, oxidative stress triggers the activation of apoptosis signal-regulating kinase 1 (ASK1), which activates downstream MAPK kinase (MKK) 4/JNK signaling cascades, leading to the initiation of apoptosis and inflammation in the ischemic area [16, 17]. This evidence concerns the gene MAPK8 and Cerebral ischemia.