Thus, in the present study, to identify the possible role of JNK in the effects of YZR extract treatments on cerebral infarction after transient MCAo, pretreatment with SP600125, an inhibitor of the JNK pathway, and pretreatment with 1% DMSO were performed in the SP (as the positive control group) and D+YZR-0.8 g groups (as the treatment group), respectively. This evidence concerns the gene MAPK8 and brain infarction.