CIRBP and memory impairment: Furthermore, MWM and SIAT results revealed that overexpressing Cirbp in the hippocampus recovered the hypoxia-induced memory impairment, with decreased escape latency (significant difference between AAV-Con hypoxia and AAV-Cirbp hypoxia, n = 8, p = 0.040 two-way ANOVA, Fig. 5C, D, Additional file 1), and increased step-down time (significant difference between AAV-Con hypoxia and AAV-Cirbp hypoxia, n = 8, p = 0.015 two-way ANOVA, Fig. 5J, Additional file 1).