Our TCGA analysis showed increased level of TRIM28 expression in various cancer types compared to normal tissues (Fig. S8A), which is consistent with previous studies that reported that TRIM28 expression is significantly higher in gastric and breast cancer tissues than their corresponding normal tissues and that downregulation of TRIM28 inhibits tumor growth and metastasis in mouse xenograft models [20, 50]. This evidence concerns the gene TRIM28 and breast carcinoma.