Moreover, the results from Transwell assays showed that the migration and invasion of BC cells in the sh-NC + oe-MALAT1 and sh-METTL3 + oe-MALAT1 group was significantly enhanced, but was reduced in the sh-METTL3 + oe-NC group compared with their controls (Fig. 2D and Additional file 3: Fig. S1D, E). This evidence concerns the gene MALAT1 and breast cancer.