In contrast, an inverse association between RBP4 levels and cardiovascular mortality [HR (95% CI) for cardiovascular mortality, tertile 3 versus tertile 1: 0.73 (0.50, 1.07)] was observed among 950 type 2 diabetes patients with 22 years of follow-up [40]. The gene discussed is RBP4; the disease is type 2 diabetes mellitus.