Input variables and their variances are as follows: HBsAg positivity rate in the general population (HBsAg, 0.3–0.7%), rate of Caucasian descent among HBsAg positive patients (85–93%), hepatitis B replication among HBsAg positive patients (HBV-VL > 2000 IU/ml, 14.7–31.4%) and hepatitis among replicative HBsAg positive patients (ALT >ULN, 43.8–59.4%). The gene discussed is GPT; the disease is hepatitis B virus infection.