Due to the limited population-based data on cHB and liver fibrosis in Germany, only a relevant HBV viral load (> 2000 IU/ml) in 14.7 to 31.4% and an elevated ALT activity in 43.8 to 59.4% were considered among HBsAg-positive patients [19, 22, 23]. This evidence concerns the gene GPT and Hepatic fibrosis.