In hepatocellular carcinoma, IFIT3 could bind signal transducer and activator of transcription 1 (STAT1) and STAT2 to enhance STAT1–STAT2 heterodimerization and nuclear translocation upon IFN-α treatment, thus promoting IFN-α effector signalling [36]. The gene discussed is IFIT3; the disease is hepatocellular carcinoma.