Although several studies have revealed that FoxO1 and FoxO3a play important roles in increasing the drug resistance in various diseases, such as ovarian cancer and chronic myelogenous leukemia [41,42], drug resistance studies involving FoxO1 and FoxO3a in melanoma have not yet been conducted, so further studies are needed to investigate this. This evidence concerns the gene FOXO1 and chronic myelogenous leukemia, BCR-ABL1 positive.