Although several studies have revealed that FoxO1 and FoxO3a play important roles in increasing the drug resistance in various diseases, such as ovarian cancer and chronic myelogenous leukemia [41,42], drug resistance studies involving FoxO1 and FoxO3a in melanoma have not yet been conducted, so further studies are needed to investigate this. The gene discussed is FOXO3; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.