AHR and fatty liver disease: On the contrary, AHR activation in rodents by environmental contaminants is associated with spontaneous hepatic steatosis characterized by the accumulation of triglycerides (Dong et al., 2019; Lee et al., 2010; Nebert, 2017), cholesterol biosynthesis impairments (Dornbos et al., 2019; Sato et al., 2008; Zhu et al., 2019) and systemic metabolic dysfunction (Zhang et al., 2015).