In this meta‐analysis, a remarkable association between CDKN2B‐AS1 gene rs4977574 A/G polymorphism and CHD was observed in the entire population under the allelic (OR: 1.18), recessive (OR: 1.36), dominant (OR: 0.71), heterozygous (OR: 1.210), homozygous (OR: 1.394) and additive (OR: 1.180) genetic models. This evidence concerns the gene CDKN2B and coronary artery disorder.