To further uncover the role of SCRAR5 in CRC, we evaluated the role of SCRAR5 abnormal expression on cell proliferation, apoptosis, and migration in CRC cells as well as in CRC xenograft mice, and the results revealed that SCARA5 upregulation remarkedly inhibited cell growth in SW480 cells, as well as inhibited tumor growth in CRC xenograft mice, which indicated that SCARA5 participated in abnormal tumor proliferation in CRC in vitro and in vivo. This evidence concerns the gene SCARA5 and neoplasm.