EWSR1 and central nervous system neoplasm: Routine diagnostic molecular profiling performed in Heidelberg in the context of the INFORM pipeline [54], the Molecular Neuropathology 2.0 or Pediatric Targeted Therapy 2.0 studies or otherwise in the Neuropathology Department of the UKHD [39, 45] revealed a small but recurring number of CNS tumors harboring fusions of the PATZ1 gene coupled to either MN1 or EWSR1 (see below).