Exploring the differential diagnostic spectrum of this observation, the recently described HGNET-MN1 tumor type, which is characterized by alternative MN1 fusions (mostly MN1:BEND2 and MN1:CXXC5), manifests more frequently with an embryonal/astroblastoma histology and shows a clearly different DNA methylation profile [46]. This evidence concerns the gene CXXC5 and astroblastoma.