Identification of the ‘new Sox2’ site (Figure 5F blue arrow in lower panel) associated with an FKBP5 transcriptional phenotype is particularly interesting, as Sox2—a TF typically associated with stemness—is neomorphically overexpressed in many lung carcinomas (relative to adjacent normal lung tissue), including A549 (31,32). The gene discussed is SOX2; the disease is lung carcinoma.