In our study, we conducted quantitative inflammatory microarray analysis in serum between PBS and Silica groups (Fig. 4a) as well as between Silica and Silica + Tet groups (Fig. 4b), combined with whole transcriptome RNAseq in PBS, Silica, and Silica + Tet groups (Fig. 4c) to identify which pathways mediate NLRP3 inflammasome activation in silicosis mice. This evidence concerns the gene NLRP3 and silicosis.