CD8A and lung adenocarcinoma: Murine models of lung adenocarcinoma have revealed that Tregs likely play a role in inhibiting CD8 T cell-mediated antitumor immunity, as depletion of Tregs has been associated with tumor cell death and elevated levels of IFNγ, granzyme A, granzyme B, and perforin in infiltrating CD8 T cells [60].