Out of 17 genes that mapped to the DISEASE database, 7 have been linked to pathogenesis of human CLL and/or other leukemias (Birc3, Wnt5a, SP140, Atr, Lyn, CD274, and Flt3), and SIFT analysis revealed that the detected mutation in Lyn is likely deleterious (Table S4). This evidence concerns the gene CD274 and leukemia.