αEβ7 is expressed predominantly by T cells, a subset of dendritic cells within mucosal surfaces and by some upper respiratory tract B cells.16 However, despite αE/CD103 serving as a major diagnostic surface marker of malignant hairy cell leukemia B cells,33 the expression of αEβ7 by gut B cell lineage cells has not been reported to date.18 Herein, we describe an unreported population of IgA+ ASC that like IEL contact or intercalate within intestinal epithelial cells (IEC). Here, ITGAE is linked to hairy cell leukemia.