Following intravitreal injections of steroids such as triamcinolone acetonide for the treatment of diabetic macular edema and uveitis, intravitreal injection of anti-vascular endothelial growth factor (VEGF) has become the most commonly performed intraocular procedure worldwide for treatment of age-related macular degeneration and other diseases1,2. This evidence concerns the gene VEGFA and age-related macular degeneration.