In addition to the alterations in the cytokine profile, we also observed that WNIN/GR-Ob (Ob-T2D) rats have decreased Leptin levels in their adipose milieu as well as in their serum when compared to the WNIN/Control rats (Figs. 2f, 3a,b; Supplementary Fig. 2a–c). The gene discussed is LEP; the disease is type 2 diabetes mellitus.