The critical determinant underlying this pathophysiological state attributes to the inflammatory milieu (enlarged adipose tissue and macrophage infiltration) with sustained release of pro-inflammatory cytokines (TNFα, IL-1β, and IL-6)5,6, In addition, acute-phase cytokines and altered inflammatory signaling pathways in adipose tissue form a linking factor for several metabolic syndromes like Obesity and Type 2 Diabetes (Ob-T2D)2. The gene discussed is TNF; the disease is obesity due to melanocortin 4 receptor deficiency.