Similarly, WNIN/GR-Ob (Ob-T2D) rats had a decreased expression of anti-inflammatory cytokines IL-10, IL-4, VEGF, β-NGF, Fractalkine, CNTF, LIX, and TIMP-1 in their adipocyte milieu and in their serum, when compared to the WNIN/Control rats (Figs. 2f, 3a,b; Supplementary Fig. 2a–c). This evidence concerns the gene TIMP1 and type 2 diabetes mellitus.