ACE2 and COVID-19: This might be the case for ACE2 where despite the ACE2 gene (receptor for SARS-CoV and SARS-CoV-2 host cell entry8) predicted loss of function, the Vero cell line has a high susceptibility to SARS-CoV and SARS-CoV-2 infection and is consequently used for the production of inactivated and attenuated COVID-19 vaccines.