Of note, upregulation of invasiveness genes, such as ITGA6, FLT1 (VEGFR-1), PDGFC, FN1, NGFR, AXL, ETS1, and others, could be significantly rescued by addition of the HAT inhibitor CTK7A (Supplementary Fig. 19a-c), supporting our hypothesis that SALL4 regulates melanoma invasiveness genes via chromatin modulating mechanisms involving histone deacetylation. This evidence concerns the gene FLT1 and melanoma.