Likewise, the neurotrophin receptor CD271/NGFR/p75NTR, which marks migratory NCSCs, is re-expressed in melanoma cells and renders them more invasive, metastatic, and therapy resistant13,15,20,21 and of note, transient ectopic expression of NGFR was shown to promote phenotype switching—the dynamic transition of melanoma cells from a proliferative to a highly invasive state22–24. The gene discussed is NGFR; the disease is melanoma.