TFAP2A and melanoma: Interestingly, this in silico approach revealed TFs regulating NC development and melanoma as putative SALL4 binding partners at melanocyte differentiation gene loci with joint SALL4 and HDAC2 peaks such as TFAP2A (Supplementary Fig. 15c, red cluster), a well-known transcriptional activator in NC cells54,55 and a regulator of melanocyte differentiation genes53.