By Co-immunoprecipitation (Co-IP) experiments we detected protein interaction between SALL4 and HDAC2 in the human melanoma cell line M010817 (Fig. 5a; Supplementary Fig. 7), which led to the hypothesis that SALL4 might repress invasiveness genes via recruitment of histone deacetylases, leading to epigenetic silencing of target genes such as invasiveness genes. Here, HDAC2 is linked to melanoma.