Interestingly, we found amongst our top SALL4-HDAC2 shared de novo DNA binding motifs matches for known transcriptional regulators of the NC that are re-expressed and have functional implication in melanoma, such as SOX10 and SOX948 or RUNX149,50, and also key regulators of melanocyte differentiation and hence melanoma, such as MITF51 or TFAP2C52,53 (Fig. 5j). Here, HDAC2 is linked to melanoma.