Thus, blocking cholesterol synthesis through miR-205 overexpression or SQLE inhibition could result in increased cholesterol uptake by increasing the expression of the low-density lipoprotein receptor (LDLR) or the cholesterol transporter SR-B1 Indeed,  it has been suggested that cholesterol uptake via SR-B1 promotes cholesterol metabolism and steroid-hormone production in androgen-dependent PCa cells30. This evidence concerns the gene LDLR and posterior cortical atrophy.