Additionally, within the nerve system development (GO:0007399) term in MGI database (http://www.informatics.jax.org/), a network of hypermethylated genes related to axon guidance (Htr7), positive regulation of astrocyte differentiation (Fryl), negative regulation of oligodendrocyte differentiation (Nfix), regulation of postsynaptic density assembly (Hoxb3), had a tendency for low expression in the F2-GDM versus the Control samples (Table 1). The gene discussed is HOXB3; the disease is gestational diabetes.