Triple immunostaining of the murine model of CRC further revealed that CD226 was positive in CD8+ T cells, while CD155 was positive in CT26 cells (Supplementary Fig. 5j, k), consistent with the immunofluorescence staining data of the human ovarian cancer revealing that CD155 was co-stained with P53 for cancer cells marker (Supplementary Fig. 5i). This evidence concerns the gene TP53 and cancer.