Wang et al. showed that the complete loss of Akt1/2 could induce hepatocarcinogenesis, and the deletion of one Akt1 allele with complete loss of Akt2 is insufficient to drive the appearance of HCC [88], indicating that there might be possible for the treatment of Akt inhibitor with an acceptable toxicity and minimal hepatocarcinogenesis risk. Here, AKT2 is linked to hepatocellular carcinoma.