Notably, in liver tissues of 6-month-old pten;tp53 cKO fish, even more phenotypic characteristics of high-grade HCC were observed, including haemorrhage and swollen bodies (Fig. 4dxii) and invasion of tumour cells into blood vessels (Fig. 4dxiii), the pancreas (Fig. 4dxiv), and the kidney (Fig. 4dxv). Here, TP53 is linked to neoplasm.