TP53 and hepatocellular carcinoma: Notably, in liver tissues of 6-month-old pten;tp53 cKO fish, even more phenotypic characteristics of high-grade HCC were observed, including haemorrhage and swollen bodies (Fig. 4dxii) and invasion of tumour cells into blood vessels (Fig. 4dxiii), the pancreas (Fig. 4dxiv), and the kidney (Fig. 4dxv).