The cancer incidence rates and the proportions of high-grade malignancy (grades II/III) induced in pten;tp53 cKO fish were much higher than those in pten KO fish (Fig. 5a, b), consistent with the trend in the mortality rates in pten KO, pten;tp53 cKO, and fabp10WT control fish (Fig. 4c). Here, PTEN is linked to cancer.