qRT-PCR confirmed elevated circIGF2BP3 expression in NSCLC cells transfected with the circIGF2BP3 overexpression plasmid and decreased expression in NSCLC cells following circIGF2BP3 knockdown; importantly, the linear IGF2BP3 mRNA levels did not change significantly (Fig. S2B-C). This evidence concerns the gene IGF2BP3 and non-small cell lung carcinoma.