E2F7 and non-small cell lung carcinoma: For instance, circPPKCI accelerates the proliferation and progression of NSCLC by sponging miR-545 and miR-589, thus promoting transcription factor E2F7 expression [16], while hsa_circ_0014235 increases the resistance of NSCLC cells to cisplatin by enhancing CDK4 expression [17].