An in vitro T cell-mediated killing assay showed that PKP3 silencing sensitized NSCLC cells to PBMC-mediated cytolysis and enhanced the expression of cytotoxicity-associated molecules in cocultured PBMCs, whereas PKP3 overexpression exhibited the opposite effect (Fig. 4E-G, Fig. S5F). Here, PKP3 is linked to non-small cell lung carcinoma.