TNF and neoplasm: As shown in Fig. 2E-F, circIGF2BP3 depletion alleviated tumor cell-mediated immune suppression, as determined by the expression of perforin, granzyme B (GzmB) and secreted IFN-γ and TNF-α from cocultured PBMCs, whereas circIGF2BP3 overexpression compromised the expression or secretion of these immune effectors.