CD8A and non-small cell lung carcinoma: Based on this theory, we constructed a ceRNA network by analyzing the miRNA target prediction database starBase, as illustrated in Fig. 1F. Among the molecules in this network, circIGF2BP3 was characterized as an authentic circRNA that inactivates the CD8+ T cell response in vivo and in vitro, indicating the pivotal impact of circIGF2BP3 on the immune evasion of NSCLC cells.