Our findings of a beneficial effect of valproate and resveratrol treatment in our zebrafish model of MJD, along with increasing SIRT1 activity for each, is consistent with Cunha-Santos et al. [11] previous findings that elevating SIRT1 levels in transgenic MJD mice via gene delivery or resveratrol treatment results in decreased neuropathology and motor dysfunction, respectively [11]. Here, SIRT1 is linked to Machado-Joseph disease.