ACE2 and COVID-19: Overall, there are clear hints that the prognosis of patients diagnosed with COVID-19 and DM may be associated with a simplified viral uptake by receptor angiotensin-converting enzyme 2 (ACE2), with a higher basal value of pro-inflammatory cytokines which facilitate a cytokine storm, with being hypoxemic and with elevated levels of IL-6 and AMPK/mTOR signaling pathway [40, 41].