PKP3 encodes for the 81.081kD PKP3 protein which is expressed in the desmosomes and the nucleus of the simple and the most stratified epithelia and plays a role in linking cadherins and intermediate filaments in the cytoskeleton, in cell–cell communication by enhancing the desmosomal strength, in the RNA metabolism and as transcription factor associated with cancer and metastasis [135–139]. Here, CDH17 is linked to cancer.