In our study, we found that astrocytic YAP was downregulated in aged mice and AD model mice in a Hippo kinases dependent manner, and deletion of YAP or activation of YAP in astrocytes promotes or delays the aging of the brain, respectively, indicating that senescent astrocytes by YAP downregulation may contribute to aging of the brain and AD. Here, YAP1 is linked to Alzheimer disease.