Indeed, Y‐maze test showed that the percentage number of alternations was significantly increased by XMU‐MP‐1 treatment in AD model mice and old mice, but not in the WT mice or young mice (Figure 6i–j), which suggest that activation of YAP in astrocytes improves the function of learning and memory in AD model mice and old mice. This evidence concerns the gene YAP1 and Alzheimer disease.