In summary, our studies identified unrecognized functions of YAP in preventing astrocytic senescence in vitro and in vivo, revealed the YAP‐CDK6 pathway in the negative control of astrocytic senescence, and discovered the new function of XMU‐MP‐1 in anti‐aging, which may provide new insights and targets for delaying brain aging and aging‐related neurodegenerative diseases. Here, CDK6 is linked to neurodegenerative disease.