The phosphorylation levels of the Hippo kinases such as LATS1, MST1, MOB1 and YAP were elevated significantly in the AD model mice, compared with that in wild‐type (WT) mice (Figure S1j–p), implying that the downregulation and inactivation of YAP in AD model mice was dependent on the Hippo pathway. Here, YAP1 is linked to Alzheimer disease.