Gene mutations in collagen type IV alpha 1 and alpha 2 chain (COL4A1/2) on chromosome 13q34 have been linked to a spectrum of cSVD in human, including perinatal intracerebral hemorrhage with consequent porencephaly, adult-onset intracerebral hemorrhage, lacunar infarcts, and leukoaraiosis [8–12]. This evidence concerns the gene COL4A1 and Abnormal cerebral white matter morphology.