In this post hoc analysis of the CANagliflozin cardioVascular Assessment Study (CANVAS), we investigated whether baseline values of TNFR-1, TNFR-2 and KIM-1 predict kidney, cardiovascular and heart failure (HF) outcomes in patients with type 2 diabetes at high cardiovascular risk. Here, TNFRSF1B is linked to type 2 diabetes mellitus.