Results of the association of the doubling in biomarker with outcomes in the fully adjusted model were generally similar in subgroup analyses defined by baseline patient characteristics for the kidney (Fig. 1), cardiovascular (ESM Fig. 3) and HF outcome (ESM Fig. 4), although the association between TNFR-2 and kidney outcomes may vary by sex. The gene discussed is TNFRSF1B; the disease is hydrops fetalis.