HMGB1 and Alzheimer disease: These findings are consistent with chronic alcohol exposure progressively inducing persistent HMGB1‐TLR‐MyD88‐NFκB cytokine and chemokine neuroimmune signaling that may contribute to the modest and diffuse neurodegeneration associated with AUD relative to AD and other neurodegenerative disorders that may sensitize the brain to age‐related neurodegeneration and disease.