In addition, the analysis of this topic would be furtherly complicated since the deleterious effects of some drugs, such as GCs, may be balanced by the positive effects on inflammation thus confounding this possible relationship.[31] However, it must be pointed out that although the synthetic and biologic DMARDs has led to substantial reductions of the chronic use of nonsteroidal anti-inflammatory drugs and cyclooxygenase-2 selective inhibitors in the treatment of RA, the use of these drugs is still common as self-administration by the patients due to chronic joint pain. The gene discussed is PTGS2; the disease is rheumatoid arthritis.