FOXP3 and familial pancreatic carcinoma: In recent studies, FOXP3 was suggested to play an important role in tumor development, in addition to its association with Treg function in the immune system.[13] FOXP3 expression in tumor cells has been reported in pancreatic cancer, melanoma, and other tumor cell lines.[14] The role of the FOXP3 gene in tumor development and the mechanisms that regulate FOXP3 expression has increasingly generated interest from researchers.