FOXP3 is known to be a transcriptional repressor of the oncogene SKP2. Zuo et al demonstrated that FOXP3-mediated repression of SKP2 occurred in normal and malignant breast epithelial cells in humans.[1] However, the relationship between SKP2 and FOXP3 in gastric adenocarcinoma has not been studied before. The gene discussed is FOXP3; the disease is gastric adenocarcinoma.