In our previous study, we observed that Beclin-1 expression in gastric adenocarcinoma is associated with the regulation of Tregs and the tumoral FOXP3 expression.[16] Interestingly, in the present study, we discovered that SKP2 expression was significantly related to Beclin-1 and tumoral FOXP3 expression and infiltrated Tregs in gastric adenocarcinoma. Here, FOXP3 is linked to gastric adenocarcinoma.