SKP2 and metastatic malignant neoplasm in the lymph nodes: As shown in Table 3, the univariate analyses for OS revealed an association with SKP2 expression (P = .007) (Fig. 2A), Beclin-1 expression (P < .0001), tumoral FOXP3 expression (P = .009), the number of Tregs (P = .012), a larger tumor size (P = .016), pT (P < .0001), lymph node metastasis (P = .0003), lymphatic invasion (P = .004), and recurrence (P < .0001).