SKP2 and metastatic malignant neoplasm in the lymph nodes: The univariate analyses for DFS revealed an association with SKP2 expression (P < .0001) (Fig. 2B), Beclin-1 expression (P < .0001), tumoral FOXP3 expression (P = .001), the number of Tregs (P < .0001), a larger tumor size (P = .001), pT (P < .0001), lymph node metastasis (P < .0001), lymphatic invasion (P < .0001), and neural invasion (P = .0367).