Included factors were primary tumor (T) (I, II vs III, IV), N stage (N0 vs N1–3), tumor grade (well to mod vs poor), lymphatic invasion, vascular invasion, neural invasion, SKP2 expression, Beclin-1 expression, tumoral FOXP3 expression, and number of Tregs (<15/HPFs, ≥15/HPFs). The gene discussed is SKP2; the disease is neoplasm.