Pathological diagnoses showed that 9 patients had clear-cell carcinoma, 4 had mixed renal carcinoma, 1 had XP11.2 translocation/TFE3 gene fusion associated with RCC, 2 had RCC, 1 had neuroendocrine carcinoma, 2 had eosinophilic cell tumor, and 1 had renal malignancy with unidentified direction of differentiation. The gene discussed is TFE3; the disease is renal cell carcinoma.