MDA-MB-231 breast cancer cell line was used as a model cell here, since it expresses EphA2 at a high level and has been characterized previously on ephrinA1 functionalized supported membranes (Chen et al., 2018; Greene et al., 2014; Lohmüller et al., 2013; Salaita et al., 2010; Xu et al., 2011). This evidence concerns the gene EPHA2 and breast carcinoma.