With the same cutoff value for ITGB4, when the combination of ITGB4 and CEA was used as a biomarker in the diagnosis of CRC, only 11 of 98 CRC patients were missed, but 802 of 1631 non‐CRC participants were misdiagnosed as CRC (false positives). Here, ITGB4 is linked to colorectal carcinoma.