As shown in Table 1, when 0.70 ng/mL was used as the cutoff value of ITGB4 for CRC diagnosis and only ITGB4 was used as a biomarker, 78 CRC patients were correctly diagnosed, 20 CRC patients were missed, and 764 of 1631 non‐CRC participants were misdiagnosed as CRC (false positives); thus, the misdiagnosis rate was obviously high. Here, ITGB4 is linked to colorectal carcinoma.