ITGB4 and colorectal carcinoma: The median serum ITGB4 concentration in the CRC samples was 1.396 ng/mL (Q25–Q75: 0.7327–2.104 ng/mL), which was significantly higher than that in HCs (0.4629 ng/mL, Q25–Q75: 0.182–1.026 ng/mL, p < 0.05) (Figure 1A).